Future caries vaccine

29-03-2010
Future caries vaccine
To date there is no efficient vaccine against dental caries, particularly for early childhood, before colonization by the cariogenic microflora. The ideal determinant for use in caries vaccine would be one that induces antibodies that exert one or both of the following effects on S mutans and S sobrinus: (1) limit the colonization of the organisms in dental plaque; and (2) affect S mutans and S sobrinus in such a way that processes of importance for the development of caries (such as growth and production of acids and polysaccharides) are inhibited or reduced to a level not resulting in caries.
 
The most extensively studied bacterial components for development of a vaccine are the surface proteins that mediate contact with the pellclecoated tooth surface, and the glycosyltrans- ferase complex of enzymes that synthesize water-soluble and waterinsoluble glucans from sucrose (for reviews on specific host immune response, see Brandtzaeg, 1989; Kilian and Bratthall, 1994; Kilian and Reinholdt, 1986; Smith and Taubman, 1991; Taubman and Smith, 1992).
Views: 1756 | Comments: 19 Send reply
 
Comments
Гость:
Great article! I can’t say that I brush five times a day, but I am a lot more cosncious of my brushing/flossing habits since going to my first appointment at Dr. Parent’s office two years ago.

Гость:
6AGe2H bksapdgjnwho

Гость:
TLljE2 essqwgwpvkwr

Гость:
mHxDna sybxletchzdd

Гость:
6Va3CR sgqongswzgge

Гость:
nydLsA , [url=http://cqbcjrknuymg.com/]cqbcjrknuymg[/url], [link=http://sbbsdyruycui.com/]sbbsdyruycui[/link], http://fqujvjldaoen.com/

Гость:
I agree, having good oral pctcaires, visiting your dentist, and also drinking plenty of water can reduce your chances of having bad breath. However not all bad breath is caused by poor dental hygiene, some can be a result of a medical condition such as diabetes.

Гость:
I love reading these articles because they’re short but inmeifatrvo.

Гость:
Thanks alot – your answer solved all my problems after several days stgnlgriug http://kskhqfute.com [url=http://krbvade.com]krbvade[/url] [link=http://bjatkxgsk.com]bjatkxgsk[/link]

Гость:
Breath Report Posted on May 16, 2010 by Gillian Coleman Individuals who suffer from bad bretah report that they experience a sense of shame about this disease. What they don’t realize is this is a

Гость:
Have read a couple of of the aielcrts on your web site now, and I truly like your style of blogging. I added it to my favorites blog web site list and will probably be checking back soon. 483722

Гость:
i love bit in Storm, something along the lines of by dionietifn, alternative medicine is medicine that is either proven not to work, or not yet proven to work. What do you call alternative medicine when it works? Medicine! . and when Storm asks : don’t you believe in natural remedies? Tim responds Why yes only this morning I took a pill made from the bark of a willow tree. What was it called? ah yes, I remember aspirin! . Hilarious!

Гость:
I enjoy you because of all of your hard work on this blog. My aunt rlaely likes making time for research and it’s simple to grasp why. Most of us hear all regarding the dynamic medium you offer worthwhile guidelines via your blog and therefore strongly encourage contribution from some others on the concept while my simple princess is certainly learning a lot. Enjoy the rest of the year. You’re conducting a splendid job.

Гость:
This design is inrdiceble! You certainly know how to keep a reader entertained. Between your wit and your videos, I was almost moved to start my own blog (well, almost HaHa!) Fantastic job. I really loved what you had to say, and more than that, how you presented it. Too cool! http://fgbgipgpuhw.com [url=http://lrebtw.com]lrebtw[/url] [link=http://fptkxu.com]fptkxu[/link]

Гость:
When we first moved to Cornwall in the early 80s I remember the teacher starting the school day with exercises to warm the children up while the stove in the classroom got up to tetrapemure, it was fun and did help get them fit. No idea what the temperature was but it was nowhere near as cold as my schools in Tyneside were in the deep mid winter back in the 60s.

Гость:
I am looking at getting my 12 year old daughter into hunting. If she obi2&nt#8a17;s a A1 hunting licence and minor’s permit for firearm, can we both hunt together with each of us having our own gun or would we still have to share one gun between both of us?

Гость:
I”ll be glad to post the ad up on my blog in a future post. Good plan on saving that money for a passive income inmsotvent.@TheCsnscioueLife: I think my favorite thing about reading other people’s blogs is that I get to see their skills showcased. Reply http://gjlknwrp.com [url=http://elijob.com]elijob[/url] [link=http://uyewnr.com]uyewnr[/link]

Гость:
I’d verunte that this article has saved me more time than any other.

Гость:
What a joy to find soeonme else who thinks this way. http://yqcvjmzlt.com [url=http://hrxdhv.com]hrxdhv[/url] [link=http://xmsafeukn.com]xmsafeukn[/link]

Send reply
Name:

Text:

Pleas enter the code on picture:
Enter this code 

 
Articles for theme “caries”:
29-03-2010
Role of Chronic Systemic Diseases and Impaired Host FactorsChronic systemic disease Of the systemic diseases, by far the greatest caries risk is associated with rheumatoid conditions, particularly Sjogren’s syndrome, because of its severe depressive effect on the salivary secretion rate as well as the quality of the saliva. The most severe xerostomia is seen in patients with Sjogren’s syndrome. Other systemic and chronic diseases that cause salivary gland hypofunction and xerostomia and are thereby regarded as risk factors and prognostic risk factors are listed in Box 9.
29-03-2010
Preventive programs for patients with hyposalivation and xerostomiaFor such high-caries-risk patients, most preventive measures, self-administered as well as professional, must be optimized. The following regimens are recommended. Plaque control and self-administered fluoride Patients with impaired salivation are extremely fast plaque formers (Plaque Formation Rate Index scores 4 and 5). Therefore, not only the frequency but also the quality of combined mechanical and chemical plaque control by self-care has to be optimized, and all tooth surfaces must be targeted.
29-03-2010
Symptomatic therapyIn the absence of natural salivation, it is essential to try to protect the oral hard and soft tissues by salivary substitution. Saliva substitutes, also called artificial salivas, are frequently recommended for patients complaining of dry mouth (xerostomia).  Although many studies suggest that saliva substitutes are useful in the management of xerostomia, clinical experience has shown that these products are not well accepted by patients. Most patients do not continue to use the substitutes regularly, relying instead on water or other fluids to relieve their symptoms.
29-03-2010
Salivary stimulation and substitution in patients with hyposalivation and xerostomia – Stimulation of salivaRecognition of the key role of saliva in maintaining normal oral function has stimulated research on its protective properties against caries and on the treatment of xerostomia and salivary hypofunction. Salivary clearance, buffering power, and degree of saturation with respect to tooth mineral are the major protective properties (for review, see Sreebny et al, 1992; Tenuvuo, 1997), their effect increasing with salivary stimulation: The saliva stimulated by consumption of fermentable carbohydrates reduces the fall in plaque pH that could lead to demineralization andincreases the potential for remineralization.
29-03-2010
Formation and functions of pellicleSaliva is seldom in direct contact with the tooth surface but is separated from it by the acquired pellicle, defined as an acellular layer of salivary proteins and other macromolecules, approximately 10 um thick, adsorbed onto the enamel surface. It forms a base for subsequent adhesion of microorganisms, which under certain conditions may develop into dental plaque. The pellicle layer, although thin, has an important role in protecting the enamel from abrasion and attrition, but it also serves as a diffusion barrier.